This is the earliest post I can find that mentions a similar problem that I'm having, which is, failing to open a file using an include path of "c:\php5\pear", which is not the include path specified in PHP.INI. Here is an example of the failure which shows the incorrect path reference:
Warning: require_once(System.php): failed to open stream: No such file or direct
ory in C:\wamp\www
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